Page 109 - ibdaa
P. 109
-b<¡~9¡EH -bJxF *]+°( * 108
kDbjD* ~|D*
*]+°( * < fDH¡' ~zD* ib.4¡D* H&*
The First Candidate Genes for Creativity
¤Ab~{g~6°* bgG°bC f£~|s~{Db+ fgD* f££mD* ib~6*4]D* E (Reuter et al. 2005) BbA4H"xgJH4" |sg~6*
*]+(°b+ f~8 i*3 f£E ib.4¡E 2¡/H rxgJ bE “dopaminergic” £Eb+H]D* bg£c+ yp- ¤gD* f~{D* pD gD*H
f£<*]+°( * ,4]D* < H¡' ~zD* ¡J ]B (dopamine receptor-DRD2) £Eb+H]D *]K 0*H ÉK cg~zE *& ,xA *¡0xA
¤A *]+°( * < fDH¡' ~zE DRD2 A1 ¥*& “allele” f££mD* iÉ£D* xjC*& *& ¢D*( D3 cB "+¡F" 4b~7*& bC
¢+ f££mD* ib~6*4]D* ¤A bgK +b. f£BxD* ib£sD* Eb< ¢cJ ,2b< £J5bB¡D* b~6H*& ¤A B&°* ¢< bcK Jx- 6bD* E
dgE 2xmE ¤G £J5bB¡D* f~6*42 *( ,]0*H f£Bx< f<¡mE f~6*42 É1 E D3H b& ~{J ]B ¥wD* JbcgD* |Q - bF*&
4b~7&*H £J5bB¡D* dFb/ ¢D(* Ix1&* ib<¡mE f~6*4]+ *¡EbBH b~¦K J*& bgK +b. xD* Eb< Hx1%* ¡j0b+ ¢+&* bC f+xmgD
y££~zCH]£G bA ¡g+*x- £/ tryptophan hydroxylase gene-TPHI £+ f~8 2¡/H bg0* ¢D*( BbA4H "xgJH4"
¤<*]+(°* x£gD* £+H
x~7¡' +H ¤D* *]+(°b+ TPHI £/ +4O . f£<*]+(* i*4bcg1* fg~zD *¡~¦1&O* *2K xA E f££/ ib£Q < iw1O&* ]BH
]0*H x~7¡' E ¢< B°& * ¢< *]+(°* ¤A ¢<&* ib/42 ¢< *¡~|pA allele A1 £/ ¡pJ JwD* 2*xA&°* bEQ *& ¤C *]+(*
*]+°( *H ¤BxD* *]+(°* £+H TPH "£D&*" £+ fD°]D* f£Db< f~8 2¡/H £Q c- ]BH ¤£mgD* x~7¡' D* ¢<H ¤D* *]+°*
z£DH *]+(°* i*x~7'¡+ c-xJ ° COMP SNP ¢<]J £/4¡FHx£~6 kDb. £/ bGH ¤D* *]+°( * x~7'¡EH ¥2]D*
¥]£gD* $bCwDb+ f~8 ¥*& f.ÉjD* ib£mD* wG ~9*¡D
4¡D* m)bgF jQ -H ¤c~|D* D* f£< ¢< ib.4¡D* x£.&b- ¢D*( *¡pD&* BbA4H "xgJH4" (* ¡F f£G&ÉDH
f£c~|D* ¢cD* £pgD* E gsE I¡g~zE ¢< *HyC4 D bK +b~6 h~9x< ¤gD* ib~6*4]D* fAbC j- ¥wD* -*3 ¤c~|D*
qJx~{gD*H ib.4Q ¡D* £+ f£/¡D¡£cD* iÉ<bgD* zJ k£0 ~|D* *wG f+bgC 4xcE kpcD* *wG 5yJH f£=bE]D* ¢cD* z£DH
i*5Hx+" ¢D*( BbA4H "xgJH4" 4b~7*& ]A ¤£mD* kpcD*H ¤c~|D* kpcD* £+ ,¡mD* x~QzmJ F(* Ix1&* ,4bc+H ¤c~|D*
f£AxD* )b;¡D* ¤A 4b~{g- i*5HxcD* wG *& HxD*H bE]D* fE]E ¤AH ¢~6¡D* ,x~{D* ¤A £Eb+H2 i*$¡gF
4¡~{D* x£= kpcD* ¡sE E f£FbjD* fp~|D* "¤<*]+(°* x£gD* ib£< ¤A xg~{- bF*& 9xgF &* J ¤DbgDb+H
E f0xD* wG ¤A bK g0 fD¡cE qc~|- bDH *]K J]p- *]+(°*H bEK ¡< ¤AxD* $*2&°* E ngg~z- ÉK A fE fD¡E wG (*
xE°& * bK +b~6 g/*xE h- ¥wD* ¤£mD* x£= ¤pJx~{gD* kpcD* E ~zgQ J D* *wG *& 0° *]+°( * ¡0 ¤.*4¡D* kpcD*
H*& £<]cD* ¦+ 4*x~8*( H DRD2 "£D*& " £+ bc-4°* E $¤~7 bG ¡J ]BH f£EbE&°* 8¡~|D *yK £Q gE *4K H2 ¤J ¥wD*
"FyJ*" bE*& BbA4H +¡F +¡F ¡pD* b+4H £-¡£D* bE2*( ¤A 4H2 bc~zpDb+ Jw1*% ~6¡G
¤DbgD* bjDb+ D3 ¢< D2 ]BH f£~zD* 9*xE&°b+ *]+°( * fBÉ< x~zJ *& £Eb+H]D* bcg~6° J £C q~9H&* ]A
DNA D2 £Eb+H2 EbD* hcD* |F P
9xQ - *3(* ¤D* e*x~9ÉD °K b£E |s~{D* mJ ¤DbF* x£gE" 2¡/H ¢< ]J *wGH b~|F°* ¡pF ÉK £E P j- k£0
f0xE ¤A ¢g0H f£/3¡D* f£FbGwD* ib£~|s~{Db+ f~|D* i*3 f£~|s~{D* ib~zD* E fEy0 ¢< ¥¡gpJ bC M bC x-Q ¡- ¢D*(
FyJ%* f£<*]+°( * ,4]D fgsD* i*x~7'¡Db+ c-x- f£FbGwD* *& bC FyJ*% "bGwD* cB bE